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Figure 2


Fig. 2. Elevated levels of integrin increased talin head recruitment. (A-F) Developing muscles at different stages. (A) Wild type; (B-F) elevated integrin expression (UAS::ßPS/+; UAS::{alpha}PS2/24BGal4). (A) In wild-type myoblasts, integrin levels are too low to recruit talinH-GFP, which was found in the nucleus. Overexpressed integrins (C) recruited talinH-GFP (B) to the cortex. In fully fused muscles overexpressed integrin recruited talinH-GFP (arrowheads) out of the nucleus and to the ends (D) (compare with Fig. 1C). Later on, the elevated integrin caused muscle detachment and talinH-GFP was recruited to the cortex (E), in contrast to GFP-talinC (F). Bars, 20 µm.





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