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Figure 10


Fig. 10. Model of PLD signaling in cell motility in corneal epithelial cells. Wounding stimulates PLD and/or EGFR through unknown mechanisms. PA synthesis is amplified through a positive feed-back loop. Increased PA leads to activation of the EGFR, and PLD can conversely be activated by EGFR signaling. Both EGFR and PA signaling are necessary for epithelial cell motility.





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