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Figure 3


Fig. 3. Dynamin participates in dorsal wave and lamellipodia formation. (A) Fluorescence image of a dorsal wave in a rat fibroblast stimulated for 5 minutes with PDGF that accumulates both Dyn2 (green) and actin (red) at the progressing wave structure (Orth, J. D. and M.A.M., unpublished data). (B) Dyn2 and cortactin accumulate at the leading edge of a rat fibroblast stimulated with EGF (Orth, J. D. and M.A.M., unpublished data). (C) Wild-type dynamin and Rac accumulate in the lamellipodium of an NIH3T3 fibroblast co-expressing constitutively active Rac, whereas dominant-negative Dyn2K44A (D) disrupts lamellipodial extension as well as accumulation of Rac at the lamellipodium. Confocal imaging was used to create Z-series reconstructions, indicated by the lines in (C) and (D) and shown in (C') and (D'); adapted from Schlunck et al. (Schlunck et al., 2004), reprinted with permission.





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