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Figure 4


Fig. 4. Dynamin localizes to focal adhesions, podosomes and invadopodia. Dynamin (A) colocalizes with constitutively active SrcY530F (B) in HeLa cells at the sites of focal adhesions (C, merge) (Cao, H. and M.A.M., unpublished data). Osteoclasts form a podosome ring, which accumulates both actin (D) and Dyn2 (E). (F) Confocal imaging shows the overlap of Dyn2 (green) and actin (red) at high resolution. A375MM melanoma cells demonstrate an association of Dyn2 (I) with actin (H) at invadopodia where the degradation of extracellular matrix occurs (G, arrows); adapted from Baldassarre et al. (Baldassarre et al., 2003), reprinted with permission.





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