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Figure 2


Fig. 2. Effect of selective inhibition of Rac, Rho or Cdc42 and elevation of Rho on EF growth cone guidance. See Fig. 1 for format. No drug + EF data are repeated from Fig. 1 for ease of comparison. (A) Mean angle turned since the start. #P<0.05; ##P<0.005; ###P<0.0001. (B) Frequency of cathodal (filled bars) and anodal (open bars) turning compared with no drug + EF (black bar). *P<0.05; **P=0.002; ***P<0.001. (C) The rate of neurite extension in an EF for 5 hours. #P<0.005; ##P=0.0035; ###P<0.0001. (D) Composite drawings of neurite paths for EF-treated cells. Compare with no drug in Fig. 1D. Bar, 100 µm for all drawings. ns, not significant.





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