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Fig. 5. Effects of inhibition of myosin-based contraction (using BDM or wortmannin) or PI 3-kinase (using LY294002 or wortmannin) on EF-induced growth cone guidance. Formatted as in Fig. 1. No drug + EF data are repeated from Fig. 1; ns, not significant compared with revelant no drug + EF or DMSO + EF control. (A) Mean angle turned. #P<0.05; ##P<0.0004; ###P<0.0001. (B) Frequency of turning during 5 hours. *P<0.05; ***P<0.001. (C) Growth rates during 5 hours of EF exposure. ##P=0.0002 compared with no drug + EF (black bar); P<0.0001 compared with DMSO + EF (grey bar). (D) Composite drawings of neurons in an EF (cathode to the left) for 5 hours. Bar, 100 µm for all drawings. Compare BDM and DMSO drawings to no drug + EF in Fig. 1D, and compare wortmannin and LY294002 to DMSO.
