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Fig. 6. Effect of inhibition of MAPK signalling on EF-induced growth cone guidance. Format as is Fig. 1. Control data are repeated from Fig. 1; ns, not significant. (A) Mean angle turned during 5 hours is not affected by any inhibitor. (B) Percentage of growth cones that turn cathodally or anodally during 5 hours. None of the inhibitors affected the frequency of cathodal turning and only SB202190 slightly increased the anodal frequency compared with the DMSO control; *, P<0.05; ***P<0.0001. (C) Rate of growth cone advance during 5 hours in an EF. P values compared with no drug + EF: DMSO, ###P<0.0001; SB203580, #P<0.05. P values compared with DMSO + EF: U0126 and SB202190, ###P<0.001. (D) Composite drawings of neurons in an EF (cathode to the left) for 5 hours. Bar, 100 µm for all drawings. Compare U0126 and SB202091 to DMSO at top of panel and compare SB203580 to no drug + EF in Fig. 1D.
