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Figure 4


Fig. 4. Dynamic analysis of growth cones in the presence and absence of an EF and inhibitors of the Rac and Cdc42 CRIB domains. (A) The mean angle turned at intervals of 10 minutes; n, number of growth cones. The angle turned in an EF (black spots) is no different than the no EF control (white spots) at 10 minutes; however, by 20 minutes, the angle turned is significantly more cathodal (P=0.0243) and becomes increasingly cathodal with time (P<0.005 from 30-50 minutes, and P<0.0001 from 60-180 minutes). The Rac (red spots) and Cdc42 (blue spots) peptides abolish turning for the entire 3 hours (P>0.05 throughout). (B) Frequency of growth cones that turn >15° towards the cathode. Symbols and number of growth cones are as for A. (C) The percentage of filopodia facing the cathode. The broken line indicates the expected frequency for randomly directed filopodia (50%); n, number of growth cones measured. (D) The percentage of total lamellipodial area facing the cathode. The dotted line represents the theoretical frequency for randomly directed lamellipodia (50%); n, number of growth cones.





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