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Figure 9


Fig. 9. Indirect immunofluorescence distribution of Cab308Myc in transfected INS cells. Triple immunofluorescence labeling with guinea pig anti-insulin (A, blue), rabbit anti-calnexin (B, red) and mouse anti-Myc (Cab308Myc, C, green) after 60 minutes of cycloheximide treatment. In the cell periphery, Cab308Myc primarily exists in organelles that are non-overlapping with anti-insulin (merge, D; an additional tenfold zoom of the inset from D is shown in E). (F) A different experiment using the same cells double labeled for Cab308Myc (with anti-rabbit conjugate in green) and the mAb GSA8 directed against the intact proinsulin cleavage site (with anti-mouse conjugate in red), which marks immature rather than mature secretory granules. Bar, 10 µm.





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