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Figure 2


Fig. 2. Pancreas and secretory granule phenotype in Dhcr7-/- mice at P0. Light images of thick sections (A-B) of pancreas show markedly decreased presence of dense core granules in sections of mutant pancreatic tissue (B), compared with numerous granules in Dhcr7+/+ mice (A). Electron microscopic analysis of normal exocrine granules reveal membrane-bound vesicles 0.05-1.5 µm in diameter filled with electron-dense granular material (C). In Dhcr7-/- animals, abnormal profiles include vesicles with condensed material surrounded by a light halo bound by membrane (F, arrows), fused vesicles (D,F, arrowheads), or light granular material that failed to form vesicular shaped structures altogether (E). Bars, 10 µm (A-B); 1 µm (C-F).





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