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Figure 5


Fig. 5. Fate of proteins within the regulated secretory pathway in SLOS mice. (A) In vivo expression of {alpha}-amylase was analyzed by western blot of protein from whole pancreas of newborn SLOS littermates. (B) Quantification of bands shows abundant presence of {alpha}-amylase in both WT and SLOS mutants, with SLOS tissues exhibiting a 15% decrease in accumulation at steady state. (C) Plasma levels of {alpha}-amylase activity in blood. Activity was significantly elevated by 25% (***P<0.001) in circulating blood serum of SLOS mice compared with the level in WT serum. Values are mean ± s.e.m. of five animals from each group.





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