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Figure 4


Fig. 4. The {alpha}1ß1 integrin has a major role for fibroblast adhesion to collagen IV and laminin 1, and to a lesser extent to collagen I. Wild-type and {alpha}2-deficient mouse fibroblasts were seeded on wells coated with collagen I, collagen IV, laminin 1 and laminin 5, as indicated, in the absence (-) or the presence of function-blocking antibodies (20 µg/ml) against integrin {alpha}1, {alpha}2 and ß1 subunits. After 30 minutes of incubation, the extent of cell adhesion was determined as in Fig. 2. The results were expressed as a percentage of the control without antibodies set as 100%.





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