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Figure 4


Fig. 4. The NO-cGMP-PKG pathway regulates MMP-13 expression through the Cbfa-1 responsive element OSE-2. Measurement of MMP-13 promoter activity in MC3T3-E1 cells transiently transfected with pMMP-13 WT or pMMP-13 OSE-2. (A) In the absence or presence of 8-Br-cGMP (8BrcGMP). (B) In the absence or presence or DEA-NO (n=3, mean ± s.d., *P<0.05 versus non-treated with 8-Br-cGMP or DEA-NO, #P<0.05 pMMP-13 OSE-2 versus pMMP-13 WT non-stimulated with 8-Br-cGMP or DEA-NO, @P<0.05 pMMP-13 OSE-2 versus pMMP-13 WT stimulated with 8-Br-cGMP or DEA-NO).





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