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Figure 4


Fig. 4. FMRP is often found in small cytoplasmic granules. (A) Confocal z-series images of FMRP granules in a single HeLa cell. Arrows indicate a single granule in panels 2-4. (B) FMRP small cytoplasmic granules normally do not colocalize with PABP or TIA-1, constituents of stress granules. HeLa cells grown in the absence or presence of 20 µM AdOx for 24 hours were immunostained with anti-FMRP mAb (red) and anti-PABP pAb (green) left panel, or anti-FMRP mAb (red) and anti-TIA-1 pAb (green) right panel. Quantitative analysis of the number of FMRP-granule containing cells for each treatment is presented in the graph below. The number of cells analyzed for each treatment is shown in each bar.





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