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Figure 8


Fig. 8. (A) Schematic representation of Ciz1 attached to an insoluble nuclear structure via a C-terminal `anchor' (yellow circle). Red triangles indicate alternatively spliced sequences that are conditionally absent from the N-terminal (replication active) half of Ciz1. (B) Speculative model showing possible role for Ciz1 as a mediator between replication factories (grey circles) and chromatin-associated replication complexes (grey barrels).





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