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Figure 8


Fig. 8. Model for differentiation-dependent changes in the sumoylation system. The model proposes a negative-feedback mechanism to explain the transient increase in sumoylation observed during HaCaT cell differentiation. Initially, a pool of TFs, including Sp1, C/EBP and AP1, which are known to be directly stimulated by Ca2+-induced differentiation, cause upregulation of the sumoylation system. As sumoylation activity increases, these TFs are in turn modified by SUMO conjugation, which decreases their transcriptional activity and leads to a decline in expression of the sumoylation pathway genes. A second feature of the model is that increased sumoylation is an active contributor to the differentiation process, through SUMO conjugation to downstream effectors of the differentiation signals. Additional details are provided in the text.





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