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Figure 8


Fig. 8. In vivo effects of HA on bone resorption. (A-C) Mouse calvarias were implanted with collagen sheets soaked with RANKL alone or with RANKL and HA. Five days later, calvarias were collected and analysed using micro-computed tomography (µ-CT). (A,B) 3D configurations of whole TRAP-stained calvarias (A); boxed areas of A are shown in B. (C) Relative percentages of calvarial bone volume. *P<0.05 and **P<0.01 between indicated groups. (D,E) Mouse calvarias treated as above were decalcified and embedded in paraffin. Coronal sections were stained with hematoxylin and eosine. Representative sections (D) and their respective percentage of marrow area (E) are shown. **P<0.01 between indicated groups.





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