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Figure 2


Fig. 2. CCD and LB reversibly inhibit the formation of filopodia, lamellipodia and ruffles, as well as stress fiber assembly and concomitant cell spreading in post-mitotic N2A cells. Untreated N2A cells were fixed in mitosis (A) and 1 hour (B), 2 hours (C), 3 hours (D) and 4 hours (E) thereafter. Alternatively, mitotic cells were incubated with 0.1% DMSO (F), 500 ng ml-1 CCD (G), or 100 ng ml-1 LB (I) and fixed 3 hours after synchronization. To determine reversibility of drug effects, cells were treated for 3 hours either with CCD (H) or LB (J), washed and released in fresh medium for 1 hour. After fixation, cells were labeled with phalloidin and visualized with fluorescence microscopy. Arrows indicate filopodia (f), lamellipodia (l) and ruffles (r). Bars, 20 µm.





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