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Figure 3


Fig. 3. WAVE1 and WAVE2 have redundant functions at cell-cell adhesions. (A) Cells treated with the indicated siRNA were fixed and stained for E-cadherin and actin filaments. Cross and vertical sections were shown. The regions from which vertical sections were taken are indicated by white lines. Bar, 15 µm (cross sections); 5 µm (vertical sections). (B) Signal intensities of E-cadherin and actin filaments in cross sections were quantified with ImageJ software. All data are mean ± s.d. *P<0.05; **P<0.005; ***P<0.0001. Statistical significance was examined using the Student's t-test. (C) Cells treated with siRNAs against CTRL, WAVE1, WAVE2, WAVE1 + WAVE2 and Arp2 were lysed, and WAVE was detected by immunoblotting. (D) Cells treated with siRNAs against CTRL, Abi1 (440 and 764) and HSPC300 (110 and 180) siRNAs were lysed, and WAVE was detected by immunoblotting. The results of two independent experiments are shown. (E) Signal intensities of WAVE, Abi1 and HSPC300 in D were quantified with ImageJ software. All data are mean ± s.d.





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