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Figure 4


Fig. 4. Spo11+/– early pachytene cells exhibit the same number of S-foci but contain more L-foci than Spo11+/+ early pachytene cells. (A,B) Quantification of {gamma}-H2AX containing S-foci (A) and L-foci (B) in early and late Spo11+/+ and Spo11+/– pachytene cells (black and white bars, respectively). Bars represent mean numbers ±s.e.m. for each experimental group (n=3). Statistical comparisons between Spo11+/+ and Spo11+/– mice at early and late pachytene were performed using the Mann-Whitney U test. Significance is ***P<0.001. (C) Distinct repartition of L-foci in Spo11+/– and Spo11+/+ pachytene spermatocytes. Pachytene nuclei of Spo11+/+ mice (black and dark gray bars) and Spo11+/– mice (light gray and white bars) were classified according to their number of L-foci.





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