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Figure 6


Fig. 6. Sca-1 KD CSC transplantation fails to prevent cardiac remodeling after myocardial infarction. (A,B) WT mice received transplantation of either NTG- or Sca-1 KD mice-derived CSCs 1 hour after infarction. Cardiac MRI was performed 4 weeks after CSC transplantation (n=8). Arrowheads indicate akinetic regions. White bars, sham-operated. Myocardial infarction with PBS injection (light gray bars), NTG-CSC (C6, dark gray bars) or Sca-1 KD-CSC (C1, black bars) transplantation are shown. *P<0.05 vs PBS; {dagger}P<0.05 versus NTG-CSC; {ddagger}P<0.01 versus PBS injection. EF, ejection fraction; ESV, end-systolic volume; EDV, end-diastolic volume; IS, infarcted size.





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