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Figure 7


Fig. 7. Sca-1 transcripts are required for CSC proliferation and survival in vivo. (A) Immunohistochemistry of transplanted lacZ+ cells 3 days after infarction. Transplanted lacZ+ cells entering cell cycle were detected as Ki67-positive cells (arrowheads) (n=6). Myocardial infarction transplanted with NTG-CSCs (C6) and Sca-1 KD CSCs (C1) are shown. *P<0.01 versus NTG. (B) Apoptotic features (arrowheads, brown nuclei) of lacZ+ engrafted cells are shown at day 3 after NTG- or Sca-1 KD-CSC transplantation. *P<0.01 versus NTG-CSC transplantation (n=6). Bars, 50 µm in A,B.





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