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Fig. 9. Transplantation of Sca-1 KD CSCs fails to prevent myocardial apoptosis and limits neoangiogenesis after myocardial infarction partially due to the failure of paracrine effector secretion. (A) TUNEL staining revealed the apoptotic cardiomyocytes in the border zone of PBS-treated, NTG (C6)- and Sca-1 KD-CSC (C1)-transplanted hearts at day 3; (n=6). ^*P<0.01 vs PBS. P<0.01 vs NTG. (B) Capillary density of infarcted border zone of transplanted hearts at day 14 after myocardial infarction. Capillary density was measured by staining of CD31 (brown) and corrected by the area analyzed. (n=8). ^*P<0.01 vs PBS-treated mice; P<0.01 vs NTG-CSC-transplanted mice. Bars, 50 µm in A,B. (C) Relative mRNA expression levels of VEGF, HGF, and IGF1 normalized by 18S expression in NTG- and Sca-1 KD-CSCs under normoxic and hypoxic conditions (n=7). ^*P<0.01 vs NTG-CSCs under normoxia; P<0.01 vs NTG-CSCs under hypoxia.

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