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Figure 4


Fig. 4. VEGF is necessary for the Ang1-mediated rescue from TGFβ1-induced apoptosis. (A) Phase-contrast micrograph of BREC after treatment for 2 days with VEGF plus FGF2 and an additional 2 days with VEGF-Trap, FGF2, TGFβ1 plus Ang1. (B) Quantification of the effects of VEGF on the length of CLS and number of BrdU-positive cells. Inhibition of VEGF with VEGF-Trap produced a significant decrease in the length of CLS (*P<0.0001 vs VEGF after 4 days). Proliferation within a pre-established network was not significantly influenced by the presence or absence of VEGF. Concentrations of factors used: 25 ng/ml VEGF, 2.5 ng/ml FGF2, 1 ng/ml TGFβ1, 500 ng/ml Ang1, and 1 µg/ml VEGF-Trap. Bar, 100 µm.





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