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Figure 2


Fig. 2. MMP-7, ADAM10 or ADAM17 do not mediate BFT-initiated E-cadherin ectodomain shedding whereas {gamma}-secretase mediates, in part, BFT-initiated E-cadherin cleavage. Cell lysates of control or siRNA-treated [MMP-7 (A), ADAM10 (B), ADAM17 (C) or {gamma}-secretase (D) ribonucleotide pairs] HT29/C1 cells were examined by western blot for each target protein or E-cadherin (intact 120 kDa or 33 kDa degradation fragment) in the presence or absence of BFT (5 nM, 2 hours) treatment. beta-actin served as an internal protein loading control. Blots are representative of three experiments.





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