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First published online May 21, 2007

Journal of Cell Science 120, 1102e (2007)
© The Company of Biologists Limited
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In this issue

Fungal two-step to polarised growth


Figure 1

During polarised cell growth, secretory vesicles carry the materials needed to make new cellular structures to the growth site. Targeting and docking of these vesicles requires a protein complex called the exocyst and may also involve septins, filament-forming proteins best known for their role in cell division. On p. 1898, Yue Wang and co-authors investigate the roles of the exocyst and septins in polarised exocytosis by examining hyphal formation in the fungal pathogen Candida albicans. Hyphal formation involves the polarised growth of a germ tube, which is then split into individual cells by septa. By examining strains that lack Sec3p (an exocyst protein that acts as a spatial landmark for exocytosis) and/or various septins, the authors discover that hyphal growth has two phases – a Sec3p-independent phase and a Sec3p-dependent phase – that are separated by the formation of the first septin ring. They also show that the septin Cdc3p interacts with the exocyst subunits Sec3p and Sec5p and propose that septin-exocyst interactions may regulate polarised exocytosis in many eukaryotic cell types.


Related articles in JCS:

Candida albicans hyphal morphogenesis occurs in Sec3p-independent and Sec3p-dependent phases separated by septin ring formation
Chang-Run Li, Raymond Teck-Ho Lee, Yan-Ming Wang, Xin-De Zheng, and Yue Wang
JCS 2007 120: 1898-1907. [Abstract] [Full Text]  




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