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First published online May 21, 2007

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Neuronal life-saver eNRAGEd

Balancing cell division and cell death is essential for normal tissue growth during development and is controlled by a dynamic protein-protein interaction network. One pair of interacting proteins that regulates this balance during neuronal development, suggest Claudio Passananti and colleagues on p. 1852, is NRAGE (neurotrophin-receptor-interacting MAGE homolog) and Che-1, an apoptosis-antagonising transcription factor. NRAGE, which contains a C-terminal melanoma-associated antigen (MAGE) homology domain, has been identified as a pro-apoptotic molecule during neuronal development whereas Che-1 has anti-apoptotic activity in cortical neurons. The authors use two-hybrid analysis to reveal the interaction between NRAGE and the C-terminal domain of Che-1. They then show that NRAGE sequesters Che-1 in the cytoplasm and targets it for proteasome-dependent degradation. Finally, they report that Che-1 overexpression prevents NRAGE-induced cell death in vitro in neuronal cells. The authors suggest, therefore, that NRAGE and Che-1 act as executors of opposing programs that ensure commitment to cell death or survival, respectively, during neuronal development.

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NRAGE associates with the anti-apoptotic factor Che-1 and regulates its degradation to induce cell death

Maria Grazia Di Certo, Nicoletta Corbi, Tiziana Bruno, Simona Iezzi, Francesca De Nicola, Agata Desantis, Maria Teresa Ciotti, Elisabetta Mattei, Aristide Floridi, Maurizio Fanciulli, and Claudio Passananti
JCS 2007 120: 1852-1858. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?