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Figure 8


Fig. 8. STxB-containing endosomal tubules appear to persist longer in Vps26 siRNA-treated cells. (A,B) Vps26-depleted HeLa cells were incubated for 45 minutes at 37°C with (A) Alexa Fluor-488-labeled STxB alone (green), or (B) Alexa Fluor-488-labeled STxB (green) together with Alexa Fluor-568-labeled human Tf (red) and then imaged by time-lapse microscopy. In B, merged image indicates overlapping localization (yellow). (B',B") magnified images of the boxed areas in B. In addition to colocalization, the series in B' show regions in the endosomes that contain either only STxB (green arrows) or only Tf (red arrows). The series in B" show endosomal tubules that contain only STxB. Time after the start of imaging is shown in seconds. Bars, 10 µm.





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