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Figure 1


Fig. 1. Engulfment of an apoptotic cell can be broken down into four phases. Binding of the apoptotic cell to the phagocyte (A) leads to recognition (B) via a host of different receptors. Engagement of some of these leads to phagocytosis of the apoptotic cell (C) and release of anti-inflammatory cytokines. Corpse engulfment occurs via at least two evolutionarily conserved signaling modules, ultimately activating the Rac1 GTPase and actin rearrangement. Following engulfment, the corpse enters lysosomal structures (D), where components such as apoptotic-cell-derived DNA are degraded.





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