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Fig. 3. Processing of the apoptotic cell corpse can act as a feedback mechanism to regulate further engulfment by the same phagocyte. Recent evidence suggests that, following engulfment, the apoptotic cell must progress through a series of endosomes before finally entering an acidic lysosome. The figure depicts two potential modes by which the processing of the engulfed corpse may regulate further phagocytosis. Activation of RhoA during later stages of engulfment, and subsequent RhoA-mediated signaling, could inhibit further uptake. Independently, proper degradation/disposal of the apoptotic-cell-derived DNA appears to regulate further engulfment by the same phagocyte. These feedback control points may link the early and late stages of engulfment to ensure proper disposal of phagocytosed apoptotic cells.
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