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Figure 5


Fig. 5. Downregulation of cav1{alpha} disrupts normal notochord development. (A-F) Analysis of notochords in 30-hour embryos injected with control MO (A,C,E) and cav1-MO2 (B,D,F). Control MO injected embryos have large vacuoles and a tight undulating sheath (A,C). cav1-MO2 injected embryos have small vacuoles with a large amount of cellular material around the edge of the notochord (B). The sheath (s) appears to be much wider and more disorganised in cav1-MO2 injected embryos (D) compared with control MO injected embryos (C). cav1-MO2 injected embryos have many fewer caveolae and large spaces between cell membranes (F) compared with the controls (E). (G) Loss of both Cav1 and Cav3 results in a more dramatic downregulation of caveolae number. Arrowheads, membranes of individual cells; v, vacuole. Bars, 10 µm (A,B); 1 µm (C-G).





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