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Figure 9


Fig. 9. A signaling model for hypoxic activation of RhoA and Na,K-ATPase regulation in alveolar epithelial cells. Based on our current findings we propose that hypoxia stimulates oxidant production within mitochondria. These oxidants activate the RhoA/ROCK pathway, resulting in stress fiber formation and a decrease in Na,K-ATPase protein levels at the plasma membrane.





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