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Figure 6


Fig. 6. Cartoon depicting signaling pathways involved in DC maturation. In the presence of sub-optimal Toll-like receptor ligand, the signal(s) generated from cells dying in the vicinity of iDCs bind to receptors that are coupled to the RyR1, activating calcium release. This intracellular pathway leading to DC maturation through RyR1 activation is dependent upon the activity of calcineurin as it could be blocked by cyclosporine A and deltamethrin. PM, plasma membrane.





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