spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online June 25, 2007

Journal of Cell Science 120, 1304e (2007)
© The Company of Biologists Limited
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JCS
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content

In this issue

Ephrin-B1 signal for invasion


Figure 1

Ephrins function as ligands for Eph receptors in many physiological processes, including development of the nervous system. But they also have receptor-like activity themselves. On p. 2179, Ryuichi Sakai and colleagues reveal that this type of `reverse signalling' by ephrin-B1 promotes the invasive properties of cancer cells by regulating the secretion of matrix metalloproteinase 8 (MMP-8). Ephrin-B1, a transmembrane protein, is often overexpressed in highly invasive tumours. The authors show that binding of the Eph receptor B2 (EphB2) to ephrin-B1 expressed by pancreatic cancer cells promotes their secretion of MMP-8. This reverse signalling activity requires the intracellular C-terminus of ephrin-B1 and involves the activation of Arf1 GTPase, a regulator of membrane trafficking. Furthermore, report the authors, the promotion of pancreatic tumour cell invasion in vivo by ephrin-B1 also requires an intact C-terminus. Thus, they propose, the C-terminus of ephrin-B1 regulates the invasive potential of cancer cells by stimulating the secretion of MMP-8, which promotes extracellular matrix degradation and, consequently, invasion.


Related articles in JCS:

The C-terminus of ephrin-B1 regulates metalloproteinase secretion and invasion of cancer cells
Masamitsu Tanaka, Kazuki Sasaki, Reiko Kamata, and Ryuichi Sakai
JCS 2007 120: 2179-2189. [Abstract] [Full Text]  




This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JCS
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content