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Figure 1


Fig. 1. Schematic model for FGF-2 secretion. Nonclassical FGF-2 export from mammalian cells can be dissected into three steps. (1) Plasma membrane targeting; (2) membrane translocation; and (3) extracellular trapping by binding to HSPGs. FGF-2 membrane translocation does not depend on ATP hydrolysis or a membrane potential but rather is a diffusion-controlled process. Net transport to the extracellular space is established by a molecular trap consisting of HSPGs, the heparan sulfate binding sites for FGF-2 being located close to the extracellular membrane surface.





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