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Figure 7


Fig. 7. The sortilin tail contains a sequence, FLV similar to the CIMPR WLM sequence. (A) Alignment of the sequences of the cytoplasmic tails of sortilin from various species. This alignment was performed in an identical fashion to that of the CIMPR tail (see Fig. 1). The FLV sequence is highlighted by the black bar, the sortilin YXX{Phi} motif is also indicated. (B) Cells expressing the CD8-CIMPR, CD8-sortilin and the WLM-AAA and FLV-AAA mutants were analysed using the anti-CD8 uptake assay. The WLM-AAA and FLV-AAA mutants both fail to retrieve to the TGN. (C) The WLM-AAA and FLV-AAA mutants are both unstable and degraded rapidly when compared with the CD8-CIMPR and CD8-sortilin reporters respectively. Bar, 20 µm.





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