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Figure 8


Fig. 8. (A) The sortilin FLV motif can replace the CIMPR WLM motif. The WLM motif was mutated to FLV in the context of the Tail19-55 reporter. Cells expressing the Tail19-55 reporter, mutant 7 and the WLM-FLV mutant were analysed by anti-CD8 uptake assay. The WLM-FLV reporter was efficiently retrieved to the TGN to colocalise with TGN46 in a similar fashion to the Tail19-55 reporter. Bar, 20 µm. (B) The stability of the WLM-FLV reporter was determined by cycloheximide chase and found to be similar to the Tail19-55 reporter, unlike mutant 7, which was unstable and degraded.





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