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Fig. 1. The domain structures of Dvl and axin proteins. Schematic representations of Dvl2 and axin, with their ligands binding to their known structural domains PDZ (Wong et al., 2003), DEP (Wong et al., 2000) and RGS (Spink et al., 2000); the DIX and DAX domains mediate dynamic polymerisation (Schwarz-Romond et al., 2007); the sequence stretches in axin that bind to -catenin and GSK3 are also indicated (in black); residue numbers underneath domains denote the domain boundaries. Note that the main binding domain for CKI appears to be the DEP domain (Kishida et al., 2001) (see below, Fig. 6), but this kinase could also bind to the PDZ domain (Peters et al., 1999).

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