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Figure 9


Fig. 9. Concentration-dependent effects of swinholide A on GFP-Kv2.1-HA cluster size. The effect of 75 or 200 nM swinholide A on Kv2.1 cluster size was determined as illustrated in panels A and B, or C and D, respectively. (A,C) Cluster distribution on the bottom of the cell before either 75 or 200 nM swinholide treatment, respectively. (B,D) The cluster pattern 40 minutes later. In this example, 75 nM swinholide reduced the cluster number from 284 to 123 while increasing the average size from 0.34 to 0.50 µm2. There was a 1.2-fold increase in the GFP signal associated with the clusters. With the 200 nm concentration, the cluster number decreased from 485 to 113, with the average cluster area decreasing from 0.58 to 0.27 µm2. The total GFP signal that was cluster associated dropped to 3.5% of its original value.





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