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Figure 8


Fig. 8. Roles of CDK11p58 in regulation of sister chromatid cohesion during mitosis. CDK11p58 protects sister-chromatid cohesion at both the arms and at the centromere. The dashed circles denote the hypothetical protective action of CDK11p58 on chromosome cohesion rather than localization of CDK11p58 to the chromosome. SAC represents the spindle checkpoint. Premature dissociation of Bub1 and cohesion complexes occurs in CDK11-depleted cells. *Plk1 binding to kinetochore is reduced in CDK11 RNAi cells (Petretti et al., 2006), which may also influence chromosome cohesion.





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