QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online July 2, 2007

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

Adapters actin' together

Adapter proteins help to control various aspects of cellular behaviour by mediating protein–protein interactions. Now, Kathrin Kirsch and colleagues report that two closely related adapter proteins – CMS and CIN85 – modulate dynamic rearrangements of the actin cytoskeleton (see p. 2366). Both proteins contain three N-terminal Src homology 3 (SH3) domains, a proline-rich region (PR), a linker region and a C-terminal coiled-coil (CC) domain that mediates oligomerization. The authors first show that CMS is a component of podosomes (actin-rich adhesion structures) and that its entire C-terminal half is required for efficient binding to filamentous actin. They then demonstrate that CMS and CIN85 both crosslink actin to form bundles; this activity depends on their PR and CC domains and is needed for cell migration. Finally, they show that CMS and CIN85 interact through their CC domains to form heterodimers. Because CIN85 exists as different isoforms, all of which contain the CC domain, the authors propose that heterotypic interactions between these isoforms and CMS regulate its binding to actin and thus modulate cytoskeletal rearrangements.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in JCS:

Structure and function analysis of the CMS/CIN85 protein family identifies actin-bundling properties and heterotypic-complex formation

Gabriel Gaidos, Shefali Soni, Duane J. Oswald, Paul A. Toselli, and Kathrin H. Kirsch
JCS 2007 120: 2366-2377. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?