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Figure 8


Fig. 8. The two-pathway model correctly predicts axonal growth response in separate DRG subpopulations. (A) NRTN and NGF induce outgrowth in responsive subpopulations under roscovitine (Rosc) treatment (50 µM). This NTF-dependent, roscovitine-insensitive outgrowth is inhibited by SU6656 (SU) (2 µM). The schemes below the histogram show which elements of the network are active (bright colors) according to the model and which elements are inactive (faint colors) under particular conditions. (B) Two large and different subpopulations of mature mouse DRG neurons express TrkA and Ret receptor tyrosine kinases. These two receptors perceive NGF and NRTN ligand inputs, respectively. (C) The values of axonal growth activated by NRTN and NGF (100 ng/ml each) were roughly additive. All values are means ± s.e.m. of three experiments. *P<0.05; ***P<0.005.





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