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Figure 6


Fig. 6. FTI inhibitor disrupts RhoB-, but not RhoD-, dependent trafficking of SFKs. SYF–/– cells expressing Src-WT-GFP, Fyn-WT-GFP, Src-GFP S3C/S6C or Fyn-GFP C3S/C6S were treated with 10 µM L-744832 for 2 hours prior to stimulation with PDGF. Active SFK was detected using anti-P-Y416-SFK (Texas Red secondary). Solid arrows indicate SFK at cell periphery whereas broken arrows indicate SFK retained in perinuclear region. Bars, 25 µm. Quantification shown in Table S1 in supplementary material.





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