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Fig. 2. Phenotype and histological analysis of K14Cre⁺/Miz1^lox/lox mice. (A) Eight-day-old (P8) K14Cre⁺/Miz1 ^lox/lox mice (foreground) exhibit rough fur compared with control littermates. (B,C) Histological analysis of hematoxylin-stained sections revealed an impaired arrangement and wavy structure of hair follicles (C), when compared with sections taken from control mouse skin (B). (D) Sections from control mice (anagen) stained with an antibody against K14 (red). Expression of K14 was observed in the basal layer of the epidermis in the entire hair follicle. This was strong in the upper part of the hair funnel and decreased towards the hair bulb. (E) K14Cre⁺/Miz1^lox/lox mice showing strong K14 expression extended into the lower part of some hair follicles (arrows). (F,G) Boxed areas of E at a higher magnification. (H) In addition, cyst-like hair follicles occurred with hair remnants. (I-K) Ectopic strong expression of K14 in hair follicles of K14Cre⁺/Miz1^lox/lox mice which were delayed in the catagen stage. Note the extreme misorientation of one follicle in K (arrow). Bars, 400 µm (B,C,D,E,I,J); 100 µm (H,K); 50 µm (F,G).

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