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Figure 7


Fig. 7. Neurite outgrowth is reduced in Xevl-depleted otic vesicles. Vibrotome sections of the otic vesicle region of stage-35 embryos with dorsal oriented up and the otic vesicle to the right in each image. (A,B) Uninjected embryos exhibit extensive neurofilament-positive projections into the vestibulocochlear ganglion (arrowhead) and the ventromedial sensory epithelium (arrow) of the otic vesicle. (C,D) Xevl-depleted otic vesicles exhibit shorter and fewer sensory projections in both the vestibulocochlear ganglion (arrowhead) and the sensory epithelium (arrow). Neurofilament is shown in green in B,D. Preparations were co-stained with spectrin (red in B,D) to outline cell boundaries. Bar, 50 µm.





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