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Figure 10


Fig. 10. Perturbation of Notch signaling affects SP cell phenotype of late retinal progenitors. To determine whether or not Notch signaling influenced SP cell phenotype of late retinal progenitors, E18 neurospheres were transduced with NICD retrovirus or cultured in the presence of DAPT to accentuate or attenuate Notch signaling, respectively. There was an increase and decrease in the proportion of SP cells in neurospheres, transduced with NICD and those cultured in DAPT, respectively, compared with levels in the controls (A-D).





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