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Figure 4


Fig. 4. Ectopic Abcg2 expression promotes pan neural and retinal progenitor properties in late retinal progenitors. (A-I) E18 neurospheres, transduced with G1-ABCG2 retrovirus to overexpress ABCG2 or empty retrovirus as controls. There was a significant increase in the proportion of BrdU+ cells expressing pan neural progenitor marker, Nestin (A-D,I) and retinal marker, Pax6 (E-H,I) in G1-ABCG2 retrovirus-transduced neurospheres, compared with controls. (J) RT-PCR analysis revealed an increase in levels of transcripts corresponding to Pax6, Nestin and Sox2 in G1-ABCG2-transduced cells, compared with controls, corroborating the immunocytochemical analysis. Data are expressed as the mean ± s.e.m. of triplicate cultures from two different experiments. ***P<0.005 compared with levels in the G1-control. Magnification, 200x.





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