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Figure 3


Fig. 3. Effects of PrPC depletion on HttQ103 induced cytotoxicity and apoptosis in SN56 cells. The extent of cytotoxicity and apoptosis were measured in mock- and PrPC-depleted cells 48 hours after transfection with either HttQ25 or HttQ103. (A) Cell viability was measured by MTT assay as described in Materials and Methods. (B) Apoptosis was measured by immunostaining for cleaved caspase-3 using Rhodamine-conjugated secondary antibody. The data represent an average of three experiments in which 500 transfected cells were analyzed to determine caspase-3 staining. *P<0.05 and **P<0.01 compared to control cultures.





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