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Figure 8


Fig. 8. Centaurin {alpha}1 localizes to dendritic spines and regulates dendritic spine density in CA1 neurons in organotypic hippocampal slice cultures. (A) Representative dendritic segments from CA1 pyramidal cells in organotypic hippocampal slice cultures transfected with eYFP and Flag-centaurin {alpha}1. Centaurin {alpha}1 was visible in the dendritic shaft and spines (arrows). Bar, 25 µm. (B) Representative dendritic segments of CA1 pyramidal neurons from organotypic hippocampal slice cultures transfected with eYFP and either dsRed, Flag-centaurin {alpha}1 or Flag-R49K centaurin {alpha}1. Bars, 2 µm. (C) Quantification of spine density in each condition. Data represent mean ± s.e. *P<0.00016.





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