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Figure 1


Fig. 1. Morphological effects of Exo70 overexpression in neuronal cells. (A-F) Cellular morphology of non-differentiated (A-C) and NGF-induced (D-F) PC12 cells expressing YFP (A,D), YFP-Exo70 (B,E) or YFP-Exo70{Delta}C (C,F). YFP fluorescence is shown. (G) Morphometric irregularity index analysis of these treatments. Data are expressed as mean ± s.e.m. Statistical significance is indicated relative to cells expressing only YFP. **P<0.01, ***P<0.001. Statistical significance for NGF-induced cells compared with non-induced cells is P<0.001 for all transfections (Student's t-test). (H-K) Cellular morphology of hippocampal neurons expressing YFP (H,I) or YFP-Exo70 (J,K). Boxed areas in H and J are shown magnified 2.2x in I and K, respectively. Bars, 5 µm (untreated cells) and 10 µm (NGF-treated cells, neurons).





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